Does polymorphisms in PPAR and APOE genes modify associations between FADS, n-3 long-chain polyunsaturated fatty acids, and cardiometabolic markers in 8-11 year-old Danish children?

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Standard

Does polymorphisms in PPAR and APOE genes modify associations between FADS, n-3 long-chain polyunsaturated fatty acids, and cardiometabolic markers in 8-11 year-old Danish children? / Damsgaard, Camilla Trab; Vuholm, Stine; Teisen, Marie Nygaard; Stark, Ken D; Lauritzen, Lotte.

I: British Journal of Nutrition, Bind 125, Nr. 4, 2020, s. 369-376.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Damsgaard, CT, Vuholm, S, Teisen, MN, Stark, KD & Lauritzen, L 2020, 'Does polymorphisms in PPAR and APOE genes modify associations between FADS, n-3 long-chain polyunsaturated fatty acids, and cardiometabolic markers in 8-11 year-old Danish children?', British Journal of Nutrition, bind 125, nr. 4, s. 369-376. https://doi.org/10.1017/S0007114520002822

APA

Damsgaard, C. T., Vuholm, S., Teisen, M. N., Stark, K. D., & Lauritzen, L. (2020). Does polymorphisms in PPAR and APOE genes modify associations between FADS, n-3 long-chain polyunsaturated fatty acids, and cardiometabolic markers in 8-11 year-old Danish children? British Journal of Nutrition, 125(4), 369-376. https://doi.org/10.1017/S0007114520002822

Vancouver

Damsgaard CT, Vuholm S, Teisen MN, Stark KD, Lauritzen L. Does polymorphisms in PPAR and APOE genes modify associations between FADS, n-3 long-chain polyunsaturated fatty acids, and cardiometabolic markers in 8-11 year-old Danish children? British Journal of Nutrition. 2020;125(4):369-376. https://doi.org/10.1017/S0007114520002822

Author

Damsgaard, Camilla Trab ; Vuholm, Stine ; Teisen, Marie Nygaard ; Stark, Ken D ; Lauritzen, Lotte. / Does polymorphisms in PPAR and APOE genes modify associations between FADS, n-3 long-chain polyunsaturated fatty acids, and cardiometabolic markers in 8-11 year-old Danish children?. I: British Journal of Nutrition. 2020 ; Bind 125, Nr. 4. s. 369-376.

Bibtex

@article{d025088919d3431298bf6d8629813bdc,
title = "Does polymorphisms in PPAR and APOE genes modify associations between FADS, n-3 long-chain polyunsaturated fatty acids, and cardiometabolic markers in 8-11 year-old Danish children?",
abstract = "n-3 Long-chain PUFA (LCPUFA) can improve cardiometabolic blood markers but studies in children are limited. SNP in the FADS genes, which encode fatty acid desaturases, influence endogenous LCPUFA production. Moreover, SNP in genes that encode PPAR and apoE may modulate the effects of n-3 LCPUFA. We explored whether FADS polymorphisms were associated with blood cholesterol and TAG, insulin and glucose and whether polymorphisms in PPAR and APOE modified associations between FADS or n-3 LCPUFA status and the cardiometabolic blood markers. We measured fasting cholesterol and TAG, insulin, glucose and n-3 LCPUFA in 757 Danish 8-11-year-old children and genotyped SNP in FADS (rs1535 and rs174448), PPARG2 (rs1801282), PPARA (rs1800206) and APOE (rs7412+rs429358). Carriage of two FADS rs174448 major alleles was associated with lower TAG (P=0.027) and higher HDL-cholesterol (P=0.047). Blood n-3 LCPUFA was inversely associated with TAG and insulin in PPARG2 minor allele carriers and positively with LDL-cholesterol in major allele homozygotes (Pn-3LCPUFA×rs180182<0.01). Associations between n-3 LCPUFA and cardiometabolic markers were not modified by APOE genotype (Pn-3LCPUFA×APOE>0.11), but interaction between FADS rs1535 and APOE showed that rs1535 major allele homozygotes who also carried APOE2 had higher HDL-cholesterol than all other genotype combinations (Prs1535×APOE =0.019, pairwise-P<0.05). This indicates that FADS genotypes, which increase endogenous LCPUFA production, may beneficially affect children's cardiometabolic profile in a partly APOE-dependent manner. Also, the degree to which children benefit from higher n-3 LCPUFA intake may depend on their PPARG2 genotype.",
keywords = "Faculty of Science, TAG, Cholesterol, Insulin, Glucose, PUFA, Genotypes, Single nucleotide polymorphism, EPA, DHA",
author = "Damsgaard, {Camilla Trab} and Stine Vuholm and Teisen, {Marie Nygaard} and Stark, {Ken D} and Lotte Lauritzen",
note = "CURIS 2020 NEXS 277",
year = "2020",
doi = "10.1017/S0007114520002822",
language = "English",
volume = "125",
pages = "369--376",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Does polymorphisms in PPAR and APOE genes modify associations between FADS, n-3 long-chain polyunsaturated fatty acids, and cardiometabolic markers in 8-11 year-old Danish children?

AU - Damsgaard, Camilla Trab

AU - Vuholm, Stine

AU - Teisen, Marie Nygaard

AU - Stark, Ken D

AU - Lauritzen, Lotte

N1 - CURIS 2020 NEXS 277

PY - 2020

Y1 - 2020

N2 - n-3 Long-chain PUFA (LCPUFA) can improve cardiometabolic blood markers but studies in children are limited. SNP in the FADS genes, which encode fatty acid desaturases, influence endogenous LCPUFA production. Moreover, SNP in genes that encode PPAR and apoE may modulate the effects of n-3 LCPUFA. We explored whether FADS polymorphisms were associated with blood cholesterol and TAG, insulin and glucose and whether polymorphisms in PPAR and APOE modified associations between FADS or n-3 LCPUFA status and the cardiometabolic blood markers. We measured fasting cholesterol and TAG, insulin, glucose and n-3 LCPUFA in 757 Danish 8-11-year-old children and genotyped SNP in FADS (rs1535 and rs174448), PPARG2 (rs1801282), PPARA (rs1800206) and APOE (rs7412+rs429358). Carriage of two FADS rs174448 major alleles was associated with lower TAG (P=0.027) and higher HDL-cholesterol (P=0.047). Blood n-3 LCPUFA was inversely associated with TAG and insulin in PPARG2 minor allele carriers and positively with LDL-cholesterol in major allele homozygotes (Pn-3LCPUFA×rs180182<0.01). Associations between n-3 LCPUFA and cardiometabolic markers were not modified by APOE genotype (Pn-3LCPUFA×APOE>0.11), but interaction between FADS rs1535 and APOE showed that rs1535 major allele homozygotes who also carried APOE2 had higher HDL-cholesterol than all other genotype combinations (Prs1535×APOE =0.019, pairwise-P<0.05). This indicates that FADS genotypes, which increase endogenous LCPUFA production, may beneficially affect children's cardiometabolic profile in a partly APOE-dependent manner. Also, the degree to which children benefit from higher n-3 LCPUFA intake may depend on their PPARG2 genotype.

AB - n-3 Long-chain PUFA (LCPUFA) can improve cardiometabolic blood markers but studies in children are limited. SNP in the FADS genes, which encode fatty acid desaturases, influence endogenous LCPUFA production. Moreover, SNP in genes that encode PPAR and apoE may modulate the effects of n-3 LCPUFA. We explored whether FADS polymorphisms were associated with blood cholesterol and TAG, insulin and glucose and whether polymorphisms in PPAR and APOE modified associations between FADS or n-3 LCPUFA status and the cardiometabolic blood markers. We measured fasting cholesterol and TAG, insulin, glucose and n-3 LCPUFA in 757 Danish 8-11-year-old children and genotyped SNP in FADS (rs1535 and rs174448), PPARG2 (rs1801282), PPARA (rs1800206) and APOE (rs7412+rs429358). Carriage of two FADS rs174448 major alleles was associated with lower TAG (P=0.027) and higher HDL-cholesterol (P=0.047). Blood n-3 LCPUFA was inversely associated with TAG and insulin in PPARG2 minor allele carriers and positively with LDL-cholesterol in major allele homozygotes (Pn-3LCPUFA×rs180182<0.01). Associations between n-3 LCPUFA and cardiometabolic markers were not modified by APOE genotype (Pn-3LCPUFA×APOE>0.11), but interaction between FADS rs1535 and APOE showed that rs1535 major allele homozygotes who also carried APOE2 had higher HDL-cholesterol than all other genotype combinations (Prs1535×APOE =0.019, pairwise-P<0.05). This indicates that FADS genotypes, which increase endogenous LCPUFA production, may beneficially affect children's cardiometabolic profile in a partly APOE-dependent manner. Also, the degree to which children benefit from higher n-3 LCPUFA intake may depend on their PPARG2 genotype.

KW - Faculty of Science

KW - TAG

KW - Cholesterol

KW - Insulin

KW - Glucose

KW - PUFA

KW - Genotypes

KW - Single nucleotide polymorphism

KW - EPA

KW - DHA

U2 - 10.1017/S0007114520002822

DO - 10.1017/S0007114520002822

M3 - Journal article

C2 - 32713352

VL - 125

SP - 369

EP - 376

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 4

ER -

ID: 245414600