Clinical applications of bovine colostrum therapy: a systematic review
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Clinical applications of bovine colostrum therapy : a systematic review. / Rathe, Mathias; Müller, Klaus; Sangild, Per Torp; Husby, Steffen.
I: Nutrition Reviews, Bind 72, Nr. 4, 2014, s. 237-254.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Clinical applications of bovine colostrum therapy
T2 - a systematic review
AU - Rathe, Mathias
AU - Müller, Klaus
AU - Sangild, Per Torp
AU - Husby, Steffen
N1 - CURIS 2014 NEXS 061
PY - 2014
Y1 - 2014
N2 - Bovine colostrum, the first milk that cows produce after parturition, contains high levels of growth factors and immunomodulatory components. Some healthy and diseased individuals may gain health benefits by consuming bovine colostrum as a food supplement. This review provides a systematic, critical evaluation of the current state of knowledge in this area. Fifty-one eligible studies were identified from the following databases: Medline, Embase, Global Health, the Cochrane Library, and the Cumulative Index to Nursing and Allied Health Literature. Studies were heterogeneous with regard to populations, outcomes, and methodological quality, as judged by the Jadad assessment tool. Many studies used surrogate markers to study the effects of bovine colostrum. Studies suggesting clinical benefits of colostrum supplementation were generally of poor methodological quality, and results could not be confirmed by other investigators. Bovine colostrum may provide gastrointestinal and immunological benefits, but further studies are required before recommendations can be made for clinical application. Animal models may help researchers to better understand the mechanisms of bovine colostrum supplementation, the dosage regimens required to obtain clinical benefits, and the optimal methods for testing these effects in humans.
AB - Bovine colostrum, the first milk that cows produce after parturition, contains high levels of growth factors and immunomodulatory components. Some healthy and diseased individuals may gain health benefits by consuming bovine colostrum as a food supplement. This review provides a systematic, critical evaluation of the current state of knowledge in this area. Fifty-one eligible studies were identified from the following databases: Medline, Embase, Global Health, the Cochrane Library, and the Cumulative Index to Nursing and Allied Health Literature. Studies were heterogeneous with regard to populations, outcomes, and methodological quality, as judged by the Jadad assessment tool. Many studies used surrogate markers to study the effects of bovine colostrum. Studies suggesting clinical benefits of colostrum supplementation were generally of poor methodological quality, and results could not be confirmed by other investigators. Bovine colostrum may provide gastrointestinal and immunological benefits, but further studies are required before recommendations can be made for clinical application. Animal models may help researchers to better understand the mechanisms of bovine colostrum supplementation, the dosage regimens required to obtain clinical benefits, and the optimal methods for testing these effects in humans.
U2 - 10.1111/nure.12089
DO - 10.1111/nure.12089
M3 - Review
C2 - 24571383
VL - 72
SP - 237
EP - 254
JO - Nutrition Reviews
JF - Nutrition Reviews
SN - 0029-6643
IS - 4
ER -
ID: 102215684